Which disease is described as progressive dementia with beta-amyloid accumulation?

Which disease is described as progressive dementia with beta-amyloid accumulation?

• A. Alzheimer's Disease
• B. Delirium
• C. Lewy body dementia
• D. Vascular dementia

Answer: (D)

Beta-amyloid accumulation with progressive cognitive decline is a hallmark of Alzheimer’s disease. In this neurodegenerative condition, extracellular beta-amyloid plaques and intracellular tau tangles develop over time, leading to a steady decline in memory, language, and executive function. Delirium is an acute, fluctuating disturbance of consciousness rather than a slow, progressive dementia. Lewy body dementia features Lewy bodies with fluctuating cognition, visual hallucinations, and parkinsonism, rather than the primary beta-amyloid pathology. Vascular dementia arises from cerebrovascular disease and shows stepwise decline with focal neurologic signs, not the characteristic beta-amyloid buildup. So the description best fits Alzheimer’s disease.

Beta-amyloid accumulation with progressive cognitive decline is a hallmark of Alzheimer’s disease. In this neurodegenerative condition, extracellular beta-amyloid plaques and intracellular tau tangles develop over time, leading to a steady decline in memory, language, and executive function. Delirium is an acute, fluctuating disturbance of consciousness rather than a slow, progressive dementia. Lewy body dementia features Lewy bodies with fluctuating cognition, visual hallucinations, and parkinsonism, rather than the primary beta-amyloid pathology. Vascular dementia arises from cerebrovascular disease and shows stepwise decline with focal neurologic signs, not the characteristic beta-amyloid buildup. So the description best fits Alzheimer’s disease.