In geriatric pharmacology, which population is most at risk from high-risk medications?

In geriatric pharmacology, which population is most at risk from high-risk medications?

• A. Children
• B. Young adults
• C. Middle-aged adults
• D. Older adults

Answer: (D)

Older adults are most at risk from high-risk medications because aging changes how the body handles drugs and how drugs affect the body. Kidney and liver function often decline, which slows drug clearance and metabolism, causing medicines to accumulate. Body composition shifts—less total body water and more fat—alter distribution and can prolong the effects of many drugs. There’s also increased sensitivity to certain drug effects, such as confusion, sedation, dizziness, and orthostatic hypotension, which raise risks like delirium and falls. When combined with multiple chronic conditions and polypharmacy, the likelihood of adverse drug events with high-risk medications rises significantly in this population.

Older adults are most at risk from high-risk medications because aging changes how the body handles drugs and how drugs affect the body. Kidney and liver function often decline, which slows drug clearance and metabolism, causing medicines to accumulate. Body composition shifts—less total body water and more fat—alter distribution and can prolong the effects of many drugs. There’s also increased sensitivity to certain drug effects, such as confusion, sedation, dizziness, and orthostatic hypotension, which raise risks like delirium and falls. When combined with multiple chronic conditions and polypharmacy, the likelihood of adverse drug events with high-risk medications rises significantly in this population.